COMPARATIVE CHARACTERISTICS OF ANTIULCER ACTIVITY OF PLACENTAL CRYOEXTRACT UNDER DIFFERENT MODES OF APPLICATION IN THE EXPERIMENT

Peptic ulcer disease is one of the most common diseases gastrointestinal tract worldwide. Among causes disability in adult population, digestive occupy 5th place, and about 20.0–30.0% them peptic disease, which leads to permanent more than 50.0% patients. According scientific reports, prevalence this pathology due its polyetiology, clinical heterogeneity recurrent course. The aim study conduct a comparative assessment antiulcer effect placental cryoextract prophylactic, therapeutic therapeutic-prophylactic regimens models ethanol-prednisolone gastric lesions. was performed on 84 nonlinear laboratory male rats weighing 200–220 g. To simulate damage mucosa, were administered single mixture: prednisolone (20 mg/kg) dissolved 80.0% ethyl alcohol (0.6 ml / 100 g animal body weight). killed 24 h after administration mixture. drug "Cryocell-cryoextract placenta" used three modes: for prophylactic purpose – once day 5 days before administration; 60 min mixture; purposes 3 mixture following studied condition mucosa assessed macroscopically by L. V. Yakovleva scale. Macroscopic evaluation showed that mixture, severity averaged 3.7±0.37 points out five maximal points, index 3.9 SU, respectively. five-day esomeprazole resulted an activity 45.9% cases 1.8 times lower rats. Erosive-ulcerative lesions under therapeutic-and-prophylactic modes observed only 28.6% corresponded value equalled 0.3 units, 92.3%. Under regimen, practically comparable efficacy (97.4%). Conclusion. cryoextracted placenta (once mixture) accompanied lowest 22.2% 4.1 effectiveness esomeprazole. Therapeutic application led statistically significant (p<0.05) attenuation damaging effects ethanol-predniolone 92.3%,